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These are glial genes responsible for taking care of damaged brain tissue. In a new study, scientists from the University of Illinois—Chicago reveal that some genes express more actively in the human brain after death. The answer is a combination of common sense and surprise. To study the postmortem brain, researchers collected brain tissue samples from brain specialised cells speed dating patients. In Scientific Reportsthey write:. To understand this difference, we measured genome-wide transcription as a function of time after fresh tissue removal to mimic the postmortem interval.
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The scientists say they were motivated by trying to close the gap between research studies of brain issues and the living human brains we want to eventually treat. Given the importance of these studies we examined the fidelity of overall gene expression between fresh and postmortem human brain tissues for a number of brain disorders with a central focus on activity-dependent genes that are likely involved in higher cognitive human brain function.
And to do that, the scientists compared the freshest possible brain tissue to traditional postmortem brain tissue. They found a totally different landscape of expressed genes, with neuronal ones falling specialised cells speed dating activity while glial genes rose to compensate:. One cluster of rapidly declining genes was predicted to be neuronal and strongly overlapped with the activity-dependent genes. A second cluster speciwlised genes was predicted to be glial, including astrocytes and microglia. Remarkably, as the neuronal cell cluster rapidly fell, there was a reciprocal and dramatic increase in the expression of the glial cell cluster. While click percent of genes stayed stable speciqlised time, the neuronal and glial genes represent the other 20 percent.
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This research was boosted by a great resource the study team has: the University of Illinois neurorepository, a collection of samples of brain tissue samples that Loeb chairs. The samples in this study were from patients with epilepsy and other brain diseases. A British student's music has been beamed to the International Space Station after she sent a track to a former Here astronaut.
Soeed Robinson recorded a suite of eight songs inspired by air, earth, fire and water, and is attempting to have each of her tracks played in their appropriate elemental setting. The commander of three missions on the International Space Station ISS arranged to have a digital recording of the track beamed to his former posting in Earth's orbit. Studies show chemicals like BPA can seep into food.
A molecular biologist worries this can lead to major health issues like obesity and diabetes. North Korea said on Monday that the U. Security Council showed a double standard as its sanctions committee criticised the country's recent missile test as a violation of U.]
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