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The most potent are members of the genus Psilocybe , such as P. As a prodrug, psilocybin is quickly converted by the body to psilocin , which has mind-altering effects similar, in some aspects, to those of LSD , mescaline , and DMT. In general, the effects include euphoria , visual and mental hallucinations , changes in perception , a distorted sense of time , and spiritual experiences, and can also include possible adverse reactions such as nausea and panic attacks. Imagery found on prehistoric murals and rock paintings of modern-day Spain and Algeria suggests that human usage of psilocybin mushrooms predates recorded history. In Mesoamerica , the mushrooms had long been consumed in spiritual and divinatory ceremonies before Spanish chroniclers first documented their use in the 16th century. In , the Swiss chemist Albert Hofmann isolated the active principle psilocybin from the mushroom Psilocybe mexicana. Hofmann's employer Sandoz marketed and sold pure psilocybin to physicians and clinicians worldwide for use in psychedelic psychotherapy. Although the increasingly restrictive drug laws of the late s curbed scientific research into the effects of psilocybin and other hallucinogens, its popularity as an entheogen spirituality-enhancing agent grew in the next decade, owing largely to the increased availability of information on how to cultivate psilocybin mushrooms. The intensity and duration of the effects of psilocybin are variable, depending on species or cultivar of mushrooms, dosage, individual physiology, and set and setting , as was shown in experiments led by Timothy Leary at Harvard University in the early s. Once ingested, psilocybin is rapidly metabolized to psilocin, which then acts on serotonin receptors in the brain. chemistry dating site reviewsIs a new site founded by the creators Premium online dating site Is mingle2 chemistry.

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