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Have a question? This is a fact sheet intended for health professionals.
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The two major classes of polyunsaturated fatty acids PUFAs are the omega-3 and omega-6 fatty acids. Like all fatty acids, PUFAs wwoman of long chains of carbon atoms with a carboxyl group at one end of the chain and a methyl group at the other. PUFAs are distinguished from saturated and monounsaturated fatty acids by the presence of two or more double bonds between carbons within the fatty acid chain. Omega-3 fatty acids womzn have a carbon—carbon double bond located three carbons from the methyl end of the chain. Omega-3s, sometimes referred to as "n-3s," are present in certain foods such as flaxseed and fish, as well as dietary supplements such as fish oil. Several different omega-3s exist, but the majority of scientific research focuses on three: alpha-linolenic acid ALAeicosapentaenoic acid EPAand docosahexaenoic acid DHA. PUFAs are frequently designated by their number of carbon atoms and double bonds.
Introduction
ALA, for example, is known as Cn-3 because it has 18 carbons and 3 double bonds and is an n-3, or omega-3, fatty acid. Omega-6 fatty acids omega-6s have a carbon—carbon double bond that is six carbons away from the methyl end of the fatty acid chain. Linoleic acid Cn-6 and arachidonic acid Cn-6 are two of the major omega-6s.
The human body can only form carbon—carbon double bonds after the 9th carbon from the methyl end of a fatty acid [ 1 ]. Therefore, ALA and linoleic acid are considered essential fatty acids, meaning that they must be obtained from the diet [ 2 ]. ALA is present in plant oils, such as flaxseed, soybean, and canola oils [ 3 ].
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DHA and EPA are present in fish, fish oils, and krill oils, but they are originally synthesized by microalgae, not by the fish. When fish consume phytoplankton that consumed microalgae, they accumulate the omega-3s in their tissues [ 3 ]. After ingestion, dietary lipids are hydrolyzed in the 31 man dating 91 year old woman lumen [ 1 ]. The hydrolysis products—monoglycerides and free fatty acids—are then incorporated into bile-salt— containing micelles and absorbed into enterocytes, largely by passive diffusion.
Within intestinal cells, free fatty acids are primarily incorporated into here and enter the circulation via the lymphatic system [ 14 ]. Once in the bloodstream, lipoprotein particles circulate within the body, delivering lipids to various organs for subsequent oxidation, metabolism, or storage in adipose tissue [ 45 ].
Omega-3s play important roles in the body as components of the phospholipids that form the structures of cell membranes [ 5 ]. DHA, in particular, is especially high in the retina, brain, and sperm [ 356 ]. In addition to their structural role in cell membranes, omega-3s along with omega-6s provide energy for the body and are used to form eicosanoids.
Eicosanoids are signaling molecules that have similar chemical structures to the fatty acids from which they are derived; they have wide-ranging functions in the body's cardiovascular, pulmonary, immune, and endocrine systems [ 12 ]. The eicosanoids made from omega-6s are generally more potent mediators of inflammation, vasoconstriction, and platelet aggregation than those made from omega-3s, although there are some 31 man dating 91 year old woman [ 37 ].
Because both classes of fatty acids compete for the same desaturation enzymes, ALA is a competitive inhibitor of linoleic acid metabolism and vice versa [ 8 ]. Thus, higher concentrations of EPA and DHA than arachidonic acid tip the eicosanoid balance toward less inflammatory activity [ 9 ]. Others have concluded that such ratios are too non-specific and are insensitive to individual fatty acid levels [ ].
Most agree that raising EPA and DHA blood levels is far more important than lowering linoleic acid or arachidonic acid levels. Currently, most clinicians do not assess omega-3 status, but it can be done by measuring individual omega-3s in plasma or serum phospholipids and expressing them as the percentage of total phospholipid fatty acids by weight [ ]. Plasma and serum fatty acid values, however, can vary substantially based on an individual's most recent meal, so they do not reflect long-term dietary consumption [ 317 ].
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It is also possible to assess omega-3 status via analysis of erythrocyte fatty acids, a measurement that reflects longer-term intakes over approximately the previous days [ 1819 ]. The "omega-3 index" proposed by Harris and von Schacky reflects the content of EPA plus DHA in erythrocyte membranes expressed as a percentage of total erythrocyte fatty acids [ 2021 ]. DRI is the general term for a set of reference values used for planning and assessing nutrient intakes dating changchun healthy people. These values, which vary by age and sex, include:. Table 1 lists the current AIs for omega-3s in grams per day. Womwn infants, the AIs apply to total omega-3s.]
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